July 21, 2004Cosanti Foundation long time staff member Roger Tomalty is in Venice, Italy, to teach a Silt Cast Workshop at the IUAV School of Architecture. [Photo: Antonio Fragiacomo & text: Matteo Di Michele]Cosanti Foundation long time staff member Roger Tomalty is in Venice, Italy, to teach a Silt Cast Workshop at the IUAV School of Architecture. [Photo: Antonio Fragiacomo & text: Matteo Di Michele] [left photo] The IUAV School of Architecture in Venice is one of the most prestigious architecture schools in Italy. It has started an intensive summer program of innovative sessions with the intention of facilitating the expressive capacities of its students by putting a consistent amount of space and tools at their disposal. Important architects from all around the world were invited to participate. One of these courses, mandatory to graduate from the School, is about Paolo Soleri and Arcosanti. [right photo] Marco Felici introduces the students to Paolo Soleris LEAN ALTERNATIVE. [left photo: IUAV, right photo: Antonio Fragiacomo & text: Matteo Di Michele] The course has been organized and delivered by Architect Antonio Fragiacomo, Structural Engineer Marco Felici and Cosanti Research Associate Roger Tomalty, with the precious help of Daniela Bruni, Maurizio Ranzi (Roma Tre University), Sandra Suatoni (Istituto Italiano Per La Grafica), Lorenzo Alfieri, Robert Clyde and Arcosanti residents Mary Hoadley and Matteo Di Michele. [Photo: Antonio Fragiacomo & text: Matteo Di Michele]
Multi-brand TV manufacturer Vestel is gearing up to launch a range of Freeview Play TVs in the UK market.Vestel’s Freeview Play range will include HD TVs and 4K Ultra HD models, allowing users to access Freeview’s connected DTT platform without connecting to a separate set-top box.“With this launch, we’re tapping into the real demands of consumers, offering a TV solution that can make the transition from linear to on-demand TV seamless and easy,” said Vestel’s UK commercial director, Sadi Acikalin.“Our partnership with Freeview marks our on-going commitment to meaningful innovation – real change that can genuinely transform and enhance the viewing experience of the majority of UK viewers.”
German cable operator PΫUR – the brand name for Tele Columbus Group – has upgraded some 3,500 homes in Wiesbaden, providing 1GHz bandwidth for a basic internet service without the need for additional payment.PΫUR has extended its supply agreement with local housing association the Gemeinnützige Bau- und Siedlungsgenossenschaft Wiesbaden 1950 – Geno50 – and has modernised the networks as part of the contract extension agreement.PΫUR has also connected an additional 426 apartments in the city to its fibre network. For a further 410 apartments, the operator is implementing a hybrid supply solution that will enable the homes to use return-channel services such as cable internet and telephony for the first time.The supply agreement with Geno50 now includes a basic internet connection without additional payment.Tele Columbus is also extending the PΫUR brand to Hamburg-based subsidiary Wohnen & TeleCommunication Verwaltung (WTC), which has been part of the group since 2015.
An intellectual talk about racism. I don’t like the term diversity. I think from now on, instead of diversity, they should just call it what it is: bigotry! —Craig We’re in Uncharted Territory Throughout the 1920s, the Federal Reserve’s easy-money policies helped create an enormous stock market bubble. In August 1929, the Fed raised interest rates and effectively ended the easy credit. Only a few months later, the bubble burst on Black Tuesday. The Dow lost over 12% that day. It was the most devastating stock market crash in the US up to that point. It also signaled the beginning of the Great Depression. Fast forward to today… The economy has been on life support since the 2008 financial crisis. The Fed has pumped it up with unprecedented amounts of “stimulus.” This has created enormous distortions and misallocations of capital that need to be flushed. Think of the trillions of dollars in money-printing programs—euphemistically called quantitative easing (QE) 1, 2, and 3. Meanwhile, with zero and even negative interest rates in many countries, rates are the lowest they’ve been in 5,000 years of recorded human history. This is not hyperbole. We’re really in uncharted territory. (Interest rates were never lower than 6% in ancient Greece and ranged from 4% to over 12% in ancient Rome.) The too-big-to-fail banks are even bigger than they were in 2008. They have more derivatives, and they’re much more dangerous. Allegedly, the Fed has been taking these actions to save the economy. In truth, it’s warped the economy far more drastically than it did in the ’20s. I expect the resulting crash to be that much bigger. Good one. —Judy NEVER Before Seen: The Aurora Borealis of Trading The Biggest Threat to Your Financial Well-Being The mainstream “fake news” media endlessly praises the Fed. It portrays Fed employees as a bunch of selfless, benign bureaucrats trying to save the economy. In reality, the Fed is the primary cause of most of the harmful distortions in the economy. You can blame the Fed for… Unlimited money printing Artificially low interest rates The boom/bust cycle Bailout funds to prop up “too-big-to-fail” institutions The War on Cash Cronyism in the financial industry Various asset bubbles… just to name a few. If you ask me, the Fed is the biggest threat to your financial well-being. Period. Today, That Threat May Be Imminent Last December, the Fed raised interest rates to their highest levels since the 2008 crash. That could help prick the massive bubble in the stock and bond markets. But the threat goes beyond that. Even a small rate increase could also be lethal for the US budget, which is built on credit. In other words, economic depression and currency inflation (perhaps hyperinflation) are very much in the cards. These things rarely lead to anything but bigger government, less freedom, and shrinking prosperity. Sometimes, they lead to much worse. Fortunately, you don’t need to be hostage to what’s coming. You can take a few steps today to prepare for the worst. To help you get started, our team just put together the Ultimate Crisis Playbook. With 109 pages full of tactical steps from every guru across our business, this market crash guide is designed not just to help you protect your wealth in the months ahead… but also to prosper. You can download it for free right here. Regards, Nick Giambruno Editor, Crisis Investing Reader Mailbag Today, readers weigh in on John Hunt’s recent essay on racism: Well done, but only educated people will read through it, get to the truth of the issue, and subscribe. Unfortunately, those who benefit and those who use it to their advantage don’t want to recognize that they are being used. —Joyce The Aurora Borealis, or “Northern Lights,” happens when solar particles rip through the Earth’s geomagnetic field and smash into gas atoms. Something similar exists in the stock market… It’s a powerful anomaly called “Quantum.” It appears when 3 major forces collide. As a result, the laws of risk and reward reverse. And the gains that are generated are incredible—both in their return and the speed in which they’re created.GDX: 129% in 3 hoursSONC: 400% in 18 hoursSTRA: 1,285% in 2 daysClick here to continue reading… (and to see where this anomaly will appear next). Justin’s note: Today, I’m sharing an important essay from Crisis Investing editor Nick Giambruno. Below, he explains the main cause for the harmful distortions in today’s economy—and why things will only get worse from here.Fortunately, we just put the finishing touches on the ultimate crisis report to help you protect yourself (and thrive) in the months ahead. Read on to learn more… By Nick Giambruno, editor, Crisis Investing You may recall the international spectacle Alan Greenspan sparked in 1996. In an otherwise dull and forgettable speech, Greenspan, the Federal Reserve chairman at the time, said the now-famous phrase “irrational exuberance.” Investors thought Greenspan meant the Fed was about to raise interest rates. Of course, Greenspan didn’t say the Fed would raise rates. Nor did he intend to signal that. Nonetheless, investors quickly panicked. US markets were closed at the time, but stocks in Japan and Hong Kong dropped 3%. The German stock market fell 4%. When trading started in the US the next day, the market opened down 2%. Billions of dollars of wealth vanished in 16 hours… all because one man said two words. That’s an absurd amount of power for one person to have. It’s also a shameful testament about the economy. It’s based more on the Fed’s shenanigans than actual production. After the US president, the Fed chair is the most powerful person on the planet. By simply saying the right words, the Fed can create or destroy trillions of dollars of wealth in both the US and abroad. Recommended Link “This Wednesday, I’m revealing my big crypto prediction for 2018” — Last year, Teeka’s crypto prediction could have made you rare and extraordinary gains of 696%… 1,140%… and even 14,354% — in as little as 6 months. This Wednesday, he’s revealing a new shocking prediction for 2018 in a free emergency broadcast. Click here for details. Recommended Link — Mr. Hunt, I’m not sure what world you live in, but your views and perspectives on racism vastly differ from mine. Perhaps you should stick to investments and the financial markets. —LarryIf you have any questions or suggestions for the Dispatch, send them to us right here. In Case You Missed It… Our colleague Teeka Tiwari, one of the world’s top cryptocurrency experts, has an urgent message… “I just returned from a three-month, international cryptocurrency investigation. Based on what I found, I believe we’re on the cusp of a ‘Second Boom.’” And he’s explaining all the details in a live crypto emergency broadcast on Wednesday, March 14. Teeka’s never shared this information in an in-depth presentation. To sign up for this event, click here.
One of the largest airports in the country has been branded one of the worst for accessibility, after it failed to consult with disabled people about how it could improve its services.Manchester Airport is one of just four in the UK that were said in the Civil Aviation Authority’s (CAA) annual review to be providing “poor” services to disabled passengers.Two of the others, Exeter and East Midlands, were also criticised for their failure to carry out any consultation at all with groups representing disabled people.The fourth “poor” airport, Heathrow, was criticised over the quality of its assistance service, with three-fifths of passengers who took part in a survey rating it as “unsatisfactory”.In its second annual review of accessibility at UK airports, CAA found six “very good” airports, 20 “good” and four that were categorised as “poor”*.It also found the number of disabled passengers requesting extra help at airports rose from 2.7 million in 2015 to more than three million in 2016 – an increase of more than two-thirds since 2010 – with satisfaction levels with assistance services consistently showing well over 80 per cent.Disabled passengers are entitled to free assistance when traveling by air under European Union regulations, and CAA is the regulatory body that monitors the quality of this assistance.The government is due to consult on how to improve access to air travel this autumn, while there will also be a consultation on plans to improve access across the public transport network.Those airports that rated well in the CAA report were those that “regularly consulted with people that use the assistance service”, whose staff were “regularly praised by passengers for their understanding and patience”, and where assistance was “efficient and well organised”, leading to minimal delays.Among those categorised as “very good”, Norwich had “created excellent partnerships with local disability organisations”, Glasgow Prestwick “hosted successful familiarisation and feedback events with charities representing people with sensory impairments and with learning disabilities”, while staff at Inverness Airport attended “numerous” local access panels.But CAA said it was “unacceptable” for an airport the size of Manchester to fail to carry out any consultation at all with disability organisations in 2016-17, although it said discussions about improving this situation had been “constructive”.Members of Greater Manchester Coalition of Disabled People (GMCDP) this week delivered a “damning” description of travelling through Manchester Airport. One member had to make their own way to the departure gate after arriving early in the morning for their flight and finding no assistance staff on duty.Another said there were never enough staff on duty or wheelchairs available.Some staff were said to be “kind, courteous and understanding” but many were said to treat disabled people as “little better than cattle”.Brian Hilton, GMCDP’s digital campaigns officer, who spoke this week to several members about their experiences of the airport, told Disability News Service: “Disabled people are paying the same amount for flights as everyone else but are getting an inferior service at Manchester Airport.“If Manchester Airport is serious about promoting itself as the gateway to the north it needs to up its game. It needs to talk to and listen to disabled people.“It needs to implement practices and procedures that ensure disabled people travel safely and in comfort and are not made to feel like second-class citizens.”GMCDP is the longest-established disabled people’s organisation (DPO) in the north-west of England, but Hilton said: “We have never had any contact from Manchester Airport saying ‘we would like to consult with you and your members.’“There is a huge potential for joint working and making things better.“It’s not that they are knocking on a closed door, they are knocking on an open door. We are willing to work with the airport.“We want to see Manchester Airport as a beacon for accessibility.“That can be achieved but there needs to be some will shown, some proactive action.”In May, GMCDP published its manifesto for the Greater Manchester mayoral election, which called on the airport to introduce DPO-led customer service training, and to carry out regular access audits, which Hilton said should also be done in conjunction with DPOs.A spokesman for Manchester Airport said the airport’s contractor OCS had recently recruited more than 100 new customer services staff to work with disabled passengers, and their initial training had included “hidden disability training”.A new contract with OCS should cut response and waiting times, he said.He said in a statement: “We acknowledge the CAA’s findings and comments relating to consultation with disability organisations.“As referred to by the report, this is an area we have already taken steps to address.“Starting this financial year, we have launched a disability engagement programme, with the first quarterly forum being held last month.”Organisations who have joined the forum include the disability charities Stomawise, Support Dogs, Guide Dogs, Queen Elizabeth’s Foundation for Disabled People, Alzheimer’s Society, the Motor Neurone Disease Association, Action on Hearing Loss and MS Society.The airport also plans a “Disability Expo” in November, which will “showcase” how it supports disabled passengers.He said: “We are confident that this work, coupled with the ongoing representation of a disability organisation [Disability Stockport] on our consultative committee, will lead to significant improvement in this area.“Ensuring those who need assistance enjoy a positive experience at our airport is both a priority of ours and the organisations contracted to provide such services on our behalf.“We regularly review customer satisfaction surveys relating to this area, with the majority of customers currently rating us very good.“However, we constantly strive to deliver a better experience for all our passengers and will continue to do so in the months ahead.”He added: “We have now started the journey of engagement to develop the service and improved accessibility. We’d welcome contact with GMCDP.”Meanwhile, an investigation by the Trailblazers network of young disabled campaigners – part of Muscular Dystrophy UK – has exposed the “shocking” number of UK hotels that fail to provide hoists.Hoists allow wheelchair-users to transfer into a bed or to use bathroom facilities when they cannot transfer independently, but almost 80 per cent of the 103 young disabled people who took part in the survey said they had been unable to go on holiday in the past five years because of the lack of hoist facilities in hotels.A further mystery shopping exercise found only one in 20 hotels offered the use of a free hoist.Lucy Watts, a Trailblazers member from Essex, said: “I haven’t stayed away from home since losing the ability to transfer and I’ve been unable to stay overnight purely because of the hoist issue.“Hotels having hoists would mean I’d be able to take trips away.”She added: “Disabled people face enough barriers in life. We shouldn’t be prevented from enjoying trips away because hotels won’t always make the effort to be fully accessible and inclusive.”*CAA said the results could not be compared with its first annual review as the categories have changed
4 min read Ecommerce Shop Fancy Just Laid Off a Third of Its Staff This story originally appeared on Business Insider Add to Queue Layoffs Free Webinar | July 31: Secrets to Running a Successful Family Business Learn how to successfully navigate family business dynamics and build businesses that excel. November 14, 2014 Joe Einhorn’s e-commerce shop Fancy, which was rumored to be in ~$1 billion acquisition talks with eBay in September, has laid off an estimated one-third of its staff, multiple sources tell Business Insider.A few layoffs were scattered throughout the summer, two sources say, with the largest round occurring on or about September 30. There, 10-15 staffers across different departments were handed paperwork by the company’s lawyer, Andrew Tuch. COO Michael Silverman only said a sentence or two, then dismissed the group.”Just fired 16 employees in one day with no warning and no explanation,” an anonymous reviewer wrote on Glassdoor in October. A number of Glassdoor reviewers allege that the company has a tendency to fire employees just before their stock options vest. Two former Fancy employees estimate that one-third of the company was cut that day, scaling a team of 45 US employees last year down to about 15 or 20 now. Another person who confirmed the layoffs thinks the one-third estimate is too high and estimates the the company had about 80 employees world-wide during its prime.Two executives have departed in recent months: Creative Director Jake Frey and General Merchandising Director Lee Assoulin. One source says the layoffs struck shortly after a board meeting. Roles cut include buyers, sales processors and business development.The reason for the layoffs vary depending on whom you ask. Those who are disgruntled feel the company spent too much cash and is in desperate need of a lifeboat. “If I had to speculate, [the layoffs occurred] because Fancy isn’t making enough money to support the business and pay salaries, and the investment money from last year (about $60 million) is pretty much all gone,” one person says.A SEC filing spotted by AllThingsD’s Jason Del Rey showed that executives from Fancy took about $20 million off the table during the company’s last fundraise. A source familiar with the company’s thinking admits that the filing looked bad, but says the money was distributed among a dozen early supporters of the company. “That money was distributed between 10-12 people who were part of the beginning fundraising,” this person says. “It wasn’t getting anyone super rich.” This person says the company is currently raising a new round, but wasn’t sure of the valuation.In September, Bloomberg reported that Fancy was in talks to get acquired by eBay for ~ $1 billion. One former staffer guessed layoffs might have had something to do with that.While Fancy did meet with eBay’s Marketplaces Business Unit President, Devin Wenig, a source familiar with the talks says no buyout price was ever discussed and was skeptical acquisition talks with eBay had ever occurred. This person says it was a typical business meeting, similar to one Fancy had with Twitter, which resulted in a Twitter Commerce partnership. Fancy recently pivoted its business from being a first-party merchant (storing inventory and shipping it to customers) to a third party merchant, where other businesses promote, sell and ship their own items to Fancy’s users. “What they were doing with first-party buying was — well, it was working in that it was making revenue and blah, blah, blah — but it wasn’t getting the full social shopping experience, where a user could look at whatever they wanted and get it in the same day,” a source familiar with the company’s thinking says. “When things started getting slow, Fancy had to pivot and make this third-party storefront. It’s an incredible tool. Imagine going on Shopify and buying everyone on there all in one place.”The pivot, this person says, is what forced the company to downsize.”It is clear as day what was happening with Fancy,” says the source. “We went from first party to third party merchants, so there was a group of people in charge of that. Fancy tried to repurpose as many of those people into other roles as possible but at the end of the day, it’s a startup and when it pivots it pivots…[Layoffs are] always unfortunate but at the end of the day, Fancy is a startup that is still young and agile.”Fancy COO Michael Silverman and CEO Joe Einhorn did not return requests for comment. Next Article Alyson Shontell –shares Register Now »
As a debate raged across the Internet Monday over whether the mysterious founder of the bitcoin digital currency had finally been identified, executives at a major bitcoin conference in New York had a simple message: we’ve moved on.That’s because bitcoin, the digital currency, has largely been supplanted by blockchain, the technology that underlies it, as the main interest of investors, technology companies and financial institutions.”If there is a 100 percent opportunity in the blockchain, bitcoin, or the currency, is only 1 percent of it,” said Jerry Cuomo, vice president, Blockchain Technologies at International Business Machines Corp. “So there is a whole 99 percent that has broad applications across the broad industries.”Over the past year numerous Wall Street firms, led by Goldman Sachs, have declared their commitment to pursuing blockchain as a potential revolutionary technology for tracking and clearing financial transactions.The blockchain technology works by creating permanent, public “ledgers” of all transactions that could potentially replace complicated clearing and settlement systems with one simple ledger.Still, bitcoin is by far the largest implementation of blockchain technology and there is considerable debate as to whether one can truly develop without the other.”Bitcoin is still the only blockchain-enabled, cross-border large scale, provable application that’s actually in production,” said Joseph Guastella, a principal at Deloitte Consulting in New York. “Bitcoin as a currency may not be as relevant as it was in many ways, but it actually is relevant as a proof case for the blockchain technology.”Bitcoins are created through a “mining” process, in which specialized computers solve complex math problems in exchange for bitcoins. One bitcoin is equivalent to $444.75 late on Monday and trade on various exchanges around the world.But bitcoin transaction volume has been in decline over the past six months amid a bitter split over technical changes in the protocol that are needed to increase the capacity of the system that produces them. Because the cryptocurrency has no formal governance, it relies on a core group of developers for direction – and they are sharply divided over the changes.But that debate was of relatively little concern to the Blockchain enthusiasts gathered in New York.Australian tech entrepreneur Craig Wright identified himself on Monday as the creator of controversial digital currency bitcoin.”It’s irrelevant because his announcement doesn’t solve a problem or resolve a conflict,” said Bharat Solanki, managing director at Cambrian Consulting in New York.”It probably helps to determine the origins of bitcoin but only for recognition,” Solanki said.For Naoki Taniguchi, a global innovation expert at The Bank of Tokyo-Mitsubishi UFJ Ltd. in San Francisco, he does not really care about who created bitcoin.”It’s all about the blockchain,” he said.(Reporting by Gertrude Chavez-Dreyfuss; Editing by Jonathan Weber, Bernard Orr) 2019 Entrepreneur 360 List Bitcoin The only list that measures privately-held company performance across multiple dimensions—not just revenue. –shares Next Article 3 min read This story originally appeared on Reuters Banks, Tech Companies Move on From Bitcoin to Blockchain Add to Queue Reuters Image credit: REUTERS/BENOIT TESSIER/FILE PHOTO May 3, 2016 Apply Now »
Content Hub Helps Marketers Collaborate, Plan and Create Engaging Content for Their Target Audiences by Providing Centralized Content Insights and Analysis Across Digital ChannelsSocialbakers, the leading unified marketing platform, announced the release of Content Hub, the go-to place for marketers to collaborate, plan and create engaging content by leveraging AI-powered content intelligence. Content Hub empowers organizations to create content strategies that deliver compelling experiences to their target audiences. With deep content insights, marketers can now leverage the right activation channels and effectively allocate the budget to stay competitive. Content Hub is fully integrated into the Socialbakers platform to ensure seamless workflows and efficient teamwork at scale. Content Hub was created to address the challenges marketers face as they seek to create and promote engaging content while maintaining high velocity across multiple channels. With instant access to AI-driven insights, marketers can easily personalize content for their target audiences and spend more time on content creation rather than tedious data gathering. It also makes the sentiment and performance analysis effortless across both owned and competitive profiles, so that marketers can have the insights they need when activating their content all in one place.Marketing Technology News: ada Strengthens Its Leadership Team as It Doubles Its Headcount“Content Hub is an entirely new way for marketers to work with content,” said Yuval Ben-Itzhak, CEO, Socialbakers. “With these shareable insights, marketers can now better collaborate, measure, analyze, plan and execute great content strategies from a single platform. Everyone on the team will have the deep intelligence they need to create compelling content that their audiences love.”Marketing Technology News: Veritonic Launches First Audio Score For Marketers To Understand Relative Power Of Their Creative AssetsContent Hub solves key pain points that marketers face every day:Guide content strategies with AI-powered insights – Trade incomplete data sets that require hours to collect and analyze with actionable insights; create engaging content for targeted audiences, select the right activation channels, and spend the budget smarter.Automate data collection and analysis at scale – Replace repetitive manual data collection with an all-inclusive overview of the entire competitive landscape to boost team efficiency and leave more time for productive work.Replace team barriers and from-scratch plans – Break down departmental silos and siloed solutions, quickly learn from regional performance insights, and apply best practices globally.Content Hub is now available as a fully integrated service within the Socialbakers platform.Marketing Technology News: Leadspace Acquires ReachForce to Offer Customers Even More Robust B2B Customer Data Platform Socialbakers Debuts Content Hub to Deliver Deep Content Intelligence for Digital Marketers MTS Staff WriterJuly 10, 2019, 12:12 pmJuly 10, 2019 Content HubDeep Content IntelligenceMarketing Technology NewsNewsSocialbakers Previous ArticleDMA United and Nelson Mandela Family Partner To Create New Media BusinessNext ArticleOpenText Expands Strategic Partnership with Google Cloud
Frozen II25% Star Wars Rise of Skywalker24% Disney Film% of all respondents in the UK excited to see said film Streaming Wars; Lion King beats Rise of Skywalker Ahead of Disney+ launch MTS Staff WriterJuly 16, 2019, 6:50 pmJuly 16, 2019 Disney feature filmsDisney streaming serviceFrozen IIGlobalWebIndexMarketing Technology NewsNews Previous ArticleGlobal DMARC Adoption Report Reveals Nearly 80 Percent of Companies Leave Consumer Data VulnerableNext ArticleNICE Robotic Process Automation Named a Leader in Everest Group’s PEAK Matrix for Second Consecutive Year The Lion King37% New research of 5,507 consumers aged 16-64 by GlobalWebIndex reveals ahead of a series of highly anticipated Disney feature films, including Star Wars and Frozen II, that The Lion King tops the UK’s list as the film over a third (37%) are excited to see.Top 3 upcoming Disney films people are excited to watch in the UK. Conducted in the US and UK, the research finds that already 35% of UK consumers are aware Disney will be launching their own streaming service, Disney Plus, despite not being available yet.With the service slated for launch in Q4 2019, Disney no doubt will be leveraging upcoming movie releases to effectively raise awareness, and encourage the 39% who currently do not plan on taking out a subscription.Marketing Technology News: Zeta Global and PlaceIQ Announce Strategic Partnership to Enhance the Zeta Data CloudRivals to beatJust over half (51%) of Disney fans in the UK would be willing to spend up to £10 per month for a Disney streaming service subscription.However, currently 71% of Disney fans in the UK use Netflix and 37% Amazon Prime video. Around a quarter of Disney fans state they would subscribe to Disney Plus and keep their current film/TV subscription services.Currently in the UK, 57% of consumers claim they currently spend up to £20 per month on their TV/Film subscription services.Marketing Technology News: M-Commerce Not Living up to Consumer Expectations, New Research FindsWinning back hearts and mindsWhen it comes to content that would entice UK consumer to subscribe to Disney’s streaming services, Pixar content proves most popular, with 37% stating so, closely followed by Marvel content (32%). Over a quarter (28%) state new Disney shows and films exclusive to the Disney platform would entice them.Chris Beer, senior trends analyst comments, “With Pixar proving most appealing among content that could entice consumers to subscribe to Disney Plus, the recent success of Toy Story 4 in the box office will give Disney a lot of confidence in their ambition to win a strong foothold in the UK video streaming market. The most important focus for the new service will be paying close attention to the content demands of its diverse, family-oriented audience.”Marketing Technology News: JotForm Reaches 5 Millionth User After Major Launch
Reviewed by James Ives, M.Psych. (Editor)Dec 14 2018Nova Southeastern University (NSU) researchers recently discovered that by testing the level of NER (nucleotide excision repair) gene expression, pediatric oncologists can determine the likelihood of early relapse (less than three years) in their acute lymphoblastic leukemia (ALL) patients. This is a critical finding because NER gene expression levels can now help guide doctors in their rationale for appropriate treatment targeted to each patient’s disease.Related StoriesGenetic contribution to distractibility helps explain procrastinationNew study identifies eight genetic variants associated with anorexia nervosaResearchers identify gene mutations linked to leukemia in children with Down’s syndromeALL is the most common childhood cancer. Treatment has improved dramatically due to evolving methods of determining risk factors and genetic analysis. Five-year survival rates have increased substantially from 57% in 1975 – ’77 to 92% in 2006 – ’12. Yet, the current genotoxic chemotherapy regimens are still extremely debilitating.”Our research found a correlation between high NER expression levels and early relapse of ALL among relapsing patients,” said Jean Latimer, Ph.D., director of the NSU AutoNation Institute for Breast and Solid Tumor Cancer Research and associate professor and cancer research scientist in NSU’s College of Pharmacy. “Being able to identify patients with the highest risk of early recurrence who are not detectable using present clinical measures and then treating them with a more targeted therapy is crucial to overcoming the cancer.”This is critical, according to the research recently published in the peer-reviewed journal, BMC Medical Genomics, because while ALL is much more treatable than in the past, the survival rate after relapse is poor.”By being able to accurately predict if a child’s cancer is likely to recur early or not, we may also spare many children who have low NER levels from the most toxic chemo regimens,'” said Latimer. Source:https://nsunews.nova.edu/nsu-researchers-uncover-genetic-marker-predictor-of-early-relapse-in-pediatric-all/
Reviewed by James Ives, M.Psych. (Editor)Apr 27 2019The U.S. Food and Drug Administration today approved a device, called Xvivo Perfusion System with Steen Solution Perfusate, that can temporarily ventilate, oxygenate, and pump (perfuse) preservation solution through lungs that were initially thought to be unacceptable for transplant. The device allows the transplant team to perform a more careful assessment of lung function to get a better sense of how the organs are working when they are perfused with a solution outside the body to better determine whether the lungs can then be viable for transplant.The Xvivo Perfusion System was originally granted marketing authorization in 2014 under a humanitarian device exemption (HDE), a regulatory pathway that limits the device’s use to a maximum of 8,000 patients per year. Today’s approval through the FDA’s more stringent premarket approval (PMA) pathway does not limit yearly patient use of the device, thereby allowing an increased number of lungs to be available for transplant and potentially increasing the number of patients who can benefit from this technology.Lung transplantation remains the only known life-saving treatment for end-stage lung disease, but many patients die while waiting for suitable lungs to become available for transplant. On average, only 15 percent of lungs obtained from deceased donors are suitable for transplantation. This is because the physiological function of a large number of donor lungs is questionable due to, for example, poor lung quality or possible injury, or there is inadequate time to find a suitable donor-recipient match. Approximately 2,530 lung transplants were performed last year, according to the U.S. Department of Health and Human Services.”Sadly, too many patients on transplant lists die waiting for suitable lungs. Providing patients with access to safe medical devices that have the potential to be lifesaving remains a top FDA priority, and we support the development of innovative technologies that can increase the donor organ pool for transplant patients in need of suitable lungs,” said Benjamin Fisher, Ph.D., director of the Division of Reproductive, Gastro-renal, Urological Devices at the FDA’s Center for Devices and Radiological Health.Related StoriesNew drug provides hope for patients with Duchenne muscular dystrophyRewiring of nerves gives movement to paralyzed arms and handsNew target identified for treatment of idiopathic pulmonary fibrosisThe Xvivo Perfusion System works by allowing marginal quality lungs that initially failed to meet standard transplant criteria to be ventilated, oxygenated and perfused at a standard normal body temperature for up to five hours. This provides an opportunity for surgeons to reassess transplant suitability, allowing them to transplant a certain percentage of lungs that were initially deemed to be unsuitable. The device consists of a perfusion cart with mechanical and electrical components that ventilate, oxygenate and perfuse the lungs with a lung preservation solution.The FDA evaluated data from a study involving 332 sets of donor lungs that were allocated into three groups: one group served as the control and were lungs initially deemed suitable for transplant that were provided to 116 recipients after standard preservation; one group were lungs initially deemed unsuitable for transplant and, after being perfused with the Xvivo Perfusion System, were implanted into 110 recipients; the third group were perfused with the Xvivo Perfusion System and were still deemed not suitable after the perfusion, and therefore were not implanted into patients. The one-year survival rate was 94 percent for the control group compared to 86.4 percent for the lung perfusion patients. The difference in rates was not deemed to be clinically significant.The most common adverse events associated with this device include acute rejection, bronchial complications, respiratory failure and infections.The FDA granted the premarket approval to Xvivo Perfusion Inc. Premarket approval is the most stringent type of device marketing application required by FDA and is based on a determination by the FDA that the PMA application contains sufficient valid scientific evidence to provide reasonable assurance that the device is safe and effective for its intended use(s). Source:https://www.fda.gov
According to researchers, this new method of diagnosing prostate cancers provides a clearer image of the tumour and this can help doctors decide the exact location from which the biopsy could be taken to be sure about the cancer. The team says that some men are at low risk of the malignant cancers. In these men, earlier unnecessary biopsies were performed to assess if they have the cancer. This new technique can eliminate the need for unnecessary biopsies in these men. Biopsies come with the risk of pain, bleeding, infections and injury. Eliminating unnecessary biopsies would be thus, welcome news.For the breakthrough, the PRECISION trial also won the UK Research Paper of the Year at the 2019 BMJ awards held in May. Study leader Professor Caroline Moore from UCL Division of Surgery and Interventional Science said in a statement, “This is fantastic news and means all men at risk of prostate cancer will now have an MRI scan before any biopsy. By having access to high quality MRI at the outset, doctors will be able to safely reassure men at lowest risk, and identify men most likely to benefit from treatment.” She added, “UCL has led the evidence gathering for MRI in men at risk of prostate cancer and it is great to see the UK being the first country to make a formal recommendation that it should be used in all men prior to a biopsy. The challenge now is to ensure the availability of high quality MRI across the NHS.”UCL’s Dean of Medical Sciences, Professor Mark Emberton, oversaw both the ladmark trials. He said in a statement, “We have been using MRI for men at risk of prostate cancer at UCL and UCLH for a decade, and it is heartening to see our research has come to full fruition with this unequivocal guidance, meaning all men will now get access to this cost-effective and transformative technology. Our PROMIS and PRECISION studies have shown MRI scans will result in fewer unnecessary invasive biopsies for men, and fewer important cancers missed.” He explained, “MRI for all men prior to biopsy of the prostate is the most important development in the management of men with early prostate cancer that we have had in the last 100 years.”The researchers explain that use of this technique of Multiparametric MRI would be more cost effective compared to traditional prostate biopsy because it takes less time and is more effective in diagnosing clinically significant cancers. The trial proved that a 10 minute scan could help become powerful screening tool for prostate cancers. Prof Emberton said, “I think that could revolutionise the way that we diagnose disease and hopefully identify men who would be better treated than not treated.”Related StoriesSpecial blood test may predict relapse risk for breast cancer patientsUsing machine learning algorithm to accurately diagnose breast cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe researchers add that prostate cancer is a slow growing cancer and men with the mpMRI scan saying they have no cancer at the age of 55 or 60 years, could be rest assured that they would be cancer-free for many years and even for life. Emberton said, “If your prostate comes back looking very clean … you’re probably very unlikely to develop prostate cancer. It may be once we learn a bit more about it that you need to refresh it every 10 years or something like that.”At present raised levels of the protein PSA in the blood are linked with growing prostate cancer while around 75 percent of the men with high levels of PSA do not need treatment for cancers and 15 percent with true aggressive cancers may present with normal PSA levels. This makes PSA an unreliable marker of the cancer, explain the researchers. Emberton said, “You end up with a lot of men being diagnosed with cancer that isn’t destined to kill them. What’s beautiful about MRI is it overlooks the many, many cancers which don’t need to be diagnosed.”An upcoming trial REIMAGINE this August costing £6 million would be funded by the Medical Research Council and Cancer Research UK and would include 1,000 men aged 55 to 75 for scans through two London GP surgeries. Emberton said that till date most men shied away from screening because of the uncomfortable per rectal examination (probing at the prostate with a gloved finger via the anus) and a painful biopsy. This new method is a 10 minute scan costing about £150 and can help make screening easier he said.Expert speakKaren Stalbow, the head of policy, knowledge and impact at Prostate Cancer UK hailed this new trial saying in a statement, “If the results are positive, then MRI scanning could offer a non-invasive first stage of prostate cancer diagnosis in the future.”Professor Hashim Ahmed, chairman of urology at Imperial College London, said, “In the future we might be able to justify screening all healthy older men for prostate cancer just as we do for women with breast cancer. This would be so useful as the number of men dying from prostate cancer has barely changed in the last two decades despite advances in treatment.”Prof Ros Eeles, professor of prostate cancer genetics at the Institute of Cancer Research in London, on the other hand was not so convinced. He said, “The use of MRI of the prostate will be important in general management of prostate cancer assessment. However, currently it is not at all clear that MRI will be reliable to detect all cancers. In men at higher genetic risk, there are studies being undertaken at the Institute of Cancer Research to assess if men who have a genetic predisposition to aggressive prostate cancer have changes on their MRI when they get prostate cancer. At present, it is not at all certain that it will be reliable to rely on MRI alone for this assessment.”A spokesman for NHS England said, “NHS England is already rolling out some of the latest developments in MRI scanning for prostate cancer diagnosis and care as part of the NHS Long Term Plan’s ambitions to catch more cancers earlier and save lives. This new test is potentially an exciting development that the NHS will look at as more evidence becomes available.” Sources: Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study, The Lancet, DOI:https://doi.org/10.1016/S0140-6736(16)32401-1, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32401-1/fulltext MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis, N Engl J Med 2018; 378:1767-1777, DOI: 10.1056/NEJMoa1801993, https://www.nejm.org/doi/full/10.1056/NEJMoa1801993?query=featured_home By Dr. Ananya Mandal, MDJun 9 2019Traditionally prostate cancers have been diagnosed using biopsies of the tumour masses. New research from researchers at University College London (UCL) has shown that a more accurate diagnostic means for prostate cancers is MRI scans and targeted biopsies. Following this research, the UK’s medical guidelines – National Institute for Health and Care Excellence (NICE), have been updated to include this new and more effective way of diagnosing prostate cancers.There are 130 cases of prostate cancer being diagnosed every day in the UK. The disease killed 11,631 men in 2016 say reports. Early and more effective screening and diagnosis can help save lives say experts.The NICE guidelines include multiparametric MRI (mpMRI) as the first and most important means of diagnosing clinically localized prostate cancers in men. The UCL researchers conducted two clinical trials called PROMIS and PRECISION in collaboration with University College London Hospitals (UCLH). The new guidelines were released last month. Image Credit: Engagestock / Shutterstock
A tree falls in the woods; but whether or not anyone hears it, the tree has no regrets. Nor does it experience fear, anger, relief or sadness as it topples to the ground. Trees — and all plants, for that matter — feel nothing at all, because consciousness, emotions and cognition are hallmarks of animals alone, scientists recently reported in an opinion article. The idea that plants have some degree of consciousness first took root in the early 2000s; the term “plant neurobiology” was coined around the notion that some aspects of plant behavior could be compared to intelligence in animals. Though plants lack brains, the firing of electrical signals in their stems and leaves nonetheless triggered responses that hinted at consciousness, researchers previously reported. But such an idea is bunk, according to the authors of the new article. Plant biology is complex and fascinating, but it differs so greatly from that of animals that so-called evidence of plants’ intelligence is intriguing but inconclusive, the scientists wrote. [The 5 Smartest Non-Primates on the Planet] Plants Know Their SiblingsPlants use chemical cues to recognize and cooperate with siblings, while spurring competition among rivals.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65905-plants-dont-think-or-feel.html?jwsource=cl已复制直播00:0001:2701:27Your Recommended Playlist01:33Better Bug Sprays?04:24Sperm Whale Befriends Underwater Robot01:08Why Do French Fries Taste So Bad When They’re Cold?00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoNucificTop Dr. Reveals The 1 Nutrient Your Gut Must HaveNucificUndoComparisons.org2019: Little-Known Rule in Rowland Heights, CAComparisons.org Image Gallery: Carnivorous Plants in Action In Photos: Plants in Danger of Disappearing In animals, neurobiology refers to the biological mechanisms through which a nervous system regulates behavior, according to Harvard University’s Mind Brain Behavior Interfaculty Initiative. Over millions of years, brains in diverse animal species have evolved to produce behaviors that experts identify as intelligent: Among them are reasoning and problem-solving, tool use and self-recognition. Beginning in 2006, some scientists have argued that plants possess neuron-like cells that interact with hormones and neurotransmitters, forming “a plant nervous system, analogous to that in animals,” said lead study author Lincoln Taiz, a professor emeritus of molecular, cell and developmental biology at the University of California Santa Cruz. “They even claimed that plants have ‘brain-like command centers’ at their root tips,” Taiz told Live Science in an email. This perspective makes sense if you simplify the workings of a complex brain, reducing it to an array of electrical pulses; cells in plants also communicate through electrical signals, according to the article. However, the signaling in a plant is only superficially similar to the billions of synapses firing in a complex animal brain, which is more than “a mass of cells that communicate by electricity,” Taiz said. “For consciousness to evolve, a brain with a threshold level of complexity and capacity is required,” he added. Other researchers who recently investigated the neuroscience of consciousness — awareness of one’s world and a sense of self — found that in animals, only vertebrates, arthropods and cephalopods had brains complex enough to enable them to be conscious. “If the lower animals — which have nervous systems — lack consciousness, the chances that plants without nervous systems have consciousness are effectively nil,” Taiz said. And what’s so great about consciousness, anyway? Plants can’t run away from danger, so investing energy in a body system that recognizes a threat and can feel pain would be a very poor evolutionary strategy, according to the article. “Being conscious may seem like harmless fun for plants being cared for in a garden, but imagine, for example, the plight of trees during a forest fire. I would not wish to inflict on trees the consciousness and pain of being burned alive,” Taiz said in the email. “Being unconscious is in all likelihood an advantage to plants and contributes to their evolutionary fitness,” he added. The findings were published online July 3 in the journal Trends in Plant Science. What Distinguishes Humans from Other Animals?
HC grants bail to journalist Upendra Rai in money laundering caseThe Delhi High Court has granted bail to journalist Upendra Rai, arrested in a money laundering case related to alleged extortion and dubious financial transactions, noting that he has already spent more than 13 months in custody and the trial is likely to take some time.advertisement Next Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 22:12 IST The Central Bureau of Investigation (CBI) had arrested him on May 3, 2018. (File photo)The Delhi High Court has granted bail to journalist Upendra Rai, arrested in a money laundering case related to alleged extortion and dubious financial transactions, noting that he has already spent more than 13 months in custody and the trial is likely to take some time.Justice Mukta Gupta granted the relief to Upendra Rai on furnishing a personal bond of Rs one lakh with a surety of like amount and directed him not to influence any witness or tamper with the evidence of the prosecution.The court also said he shall not leave the country without prior permission.Upendra Rai was arrested on June 8, 2018, by the Enforcement Directorate under the Prevention of Money Laundering Act (PMLA) at the Tihar jail here, moments after he secured bail in a Central Bureau of Investigation case related to alleged extortion and dubious financial transactions.The Central Bureau of Investigation (CBI) had arrested him on May 3, 2018.The Enforcement Directorate opposed his bail plea saying that merely because bail has been granted to him in the two predicate offences investigated by the Central Bureau of Investigation (CBI) could not be the sole criteria to grant him the relief in the money laundering case.A trial court had in January declined to grant him bail in the case.The high court said since Upendra Rai has already undergone more than one year of custody and there being no material placed on record to show that he has tampered evidence, it is a fit case of granting bail to him.”The maximum punishment provided for the offence punishable under Section 4 Prevention of Money Laundering (PMLA) being seasons years imprisonment and the petitioner has undergone more than 1 year 1 month of custody and the trial likely to take some time, there being no material placed on record to show that the petitioner has been tampering of evidence… this court finds it to be a fit case for grant of bail to the petitioner,” the judge said.During the previous hearing, the Delhi-based scribe’s counsel had alleged in the high court that investigating agencies, Central Bureau of Investigation (CBI) and Enforcement Directorate (ED), were “playing with the liberty” of his client.The lawyer had said that the “vindictive approach” of the agencies was evident from the fact that he was being kept in custody even though his further interrogation was not required.Upendra Rai was arrested by the Central Bureau of Investigation (CBI) for allegedly indulging in dubious financial transactions, getting an airport access pass made by the Bureau of Civil Aviation Security (BCAS) by furnishing false information, alleged extortion and manipulation of an Income Tax Department case against a Mumbai-based businessman.Upendra Rai has denied all the allegations levelled against him.ALSO READ | Upendra Rai case: CBI team visits I-T Dept in Mumbai, collects crucial dataALSO READ | Upendra Rai raids: CDRs of ED officer, ex-corporate affairs joint secy under probeALSO WATCH | Nirav Modi scam involving fraudulent LoUs a systemic issue, says Meera SanyalFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShahrukh Tags :Follow Money launderingFollow CrimeFollow Delhi High CourtFollow Prevention of Money Laundering ActFollow CBIFollow Journalist